AICAR (250mg) – Full Report

Scientific Name: 5-Aminoimidazole-4-carboxamide ribonucleotide (Acadesine)

⚙️ Mechanism of Action

AICAR activates an enzyme called AMPK (AMP-Activated Protein Kinase), which is a key regulator of cellular energy. Activation of AMPK leads to:

• Increased glucose uptake
• Fat burning
• Enhanced mitochondrial production
• Reduced fat storage
• Mimicking the effects of physical exercise on a cellular level

🌍 General Benefits

✅ Metabolism Boost

• Promotes fat utilization as an energy source
• Improves insulin sensitivity
• Helps regulate blood sugar levels

🧠 Neuroprotective Effects

• Shows potential in enhancing brain function and protecting nerve cells (based on animal studies)

⚙️ Exercise-Mimicking Effect

• In animal studies, AICAR improved endurance even without actual physical activity

🏋️‍♂️ Benefits for Bodybuilders

🔥 Fat Loss with Muscle Preservation

• Stimulates fat burning while preserving lean muscle mass
• Helps maintain a shredded physique during cutting phases

⚡ Enhanced Endurance and Energy

• Improves aerobic performance and reduces fatigue during long workouts

🧬 Supports Low-Carb Diets

• Helps the body rely more efficiently on fat for energy, useful during ketogenic or low-carb phases

💉 Dosage and Usage

⚠️ Note: AICAR is not approved for human use outside of research. The following is based on experimental and animal data.

• Research Dose: 250 mg daily
• Administration: Subcutaneous or intravenous injection
• Cycle Duration: 4–6 weeks
• Preferred Timing: Morning or pre-cardio session

⚠️ Potential Side Effects

• Hypoglycemia (low blood sugar)
• Gastrointestinal disturbances
• Altered liver enzyme levels
• Dizziness or fatigue
• Possible cardiac issues with overuse

🚫 Important Notes

• Banned by WADA (World Anti-Doping Agency) in competitive sports
• Not approved for therapeutic use in humans
• Should never be used without professional medical supervision